Exploring the potential of bis(thiazol-5-yl)phenylmethane derivatives as novel candidates against genetically defined multidrug-resistant Staphylococcus aureus

Antimicrobial resistance is a global health concern, particularly in Staphylococcus aureus infections. A series of bis(thiazol-5-yl)phenylmethane derivatives were tested against Gram-positive bacteria, showing a selective mechanism against S. aureus. The most active derivatives, 23a and 28b, exhibited strong bactericidal activity against S. aureus and their biofilms. These compounds bind to S. aureus MurC ligase, forming bonds with MurC residues. The compounds showed favorable cytotoxicity profiles in macrophage models, suggesting potential for further development.